Mistress centipede has the distinction of being the first full-fledged demon appearing in the series. It's Mistress Centipede who bursts out of the Bone-Eater's well and pulls Kagome back to the Sengoku period. Apparently, her remains in the Bone Eater's well were brought back to life by Kagome's proximity because the Shikon Jewel.
Her initial appearance is that of a multi-armed woman with the (regenerating) lower body of a gigantic centipede. While she was pulling Kagome down the well, the Shikon Jewel activates and Mistress Centipede is repelled by Kagome's hand. As a result, Mistress Centipede lost one of her human arms. For the time being, Mistress Centipede disappears and Kagome is captured by the people of Kade's village.
Later that night, Mistress Centipede attacks the village in a second attempt to get the Shikon Jewel. In order to lure her away from the village, Kagome runs into the forrest towards the Sacred Tree. Mistress Centipede pursues her and after biting Kagome and tossing her into the air, the Shikon Jewel falls out of Kagome's side to the ground.
Mistress Centipede swallows the Shikon Jewel and sheds her human skin, transforming into a much more formidable demon. She starts crushing Inuyasha and Kagome, and in order to save their lives, Kagome releases Inuyasha. Despite the added power of the Shikon Jewel Inuyasha easily destroys her. Despite being shred into little pieces, she starts to regenerate because of the Shikon Jewel in her body. However, Kagome spots the glowing jewel shard and Kaede removes it from Mistress Centipede's remains. Once that's done the flesh dissolves from Mistress Centipede's remains, leaving only a skeleton.
